Amiloride: A review
نویسندگان
چکیده
منابع مشابه
Amiloride. A potassium-sparing natriuretic agent.
SUMMARY Amiloride, a new, well-tolerated oral natriuretic and mild diuretic agent, has been evaluated alone and in combination with other diuretics. Its remarkable ability to promote retention rather than loss of potassium makes it a useful adjunct in the management of even the most severe edematous states. It also retards the alkalosis produced by certain of the stronger diuretics by blocking ...
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IN THE CRYSTAL OF THE TITLE COMPOUND [SYSTEMATIC NAME: 2-(3,5-diamino-6-chloro-pyrazin-2-ylcarbon-yl)guanidinium chloride methanol disolvate], C(6)H(9)ClN(7)O(+)·Cl(-)·2CH(3)OH , the components are connected by N-H⋯N, N-H⋯Cl, N-H⋯O, O-H⋯Cl and O-H⋯O hydrogen bonds into a three-dimensional network. The dihedral angle between the aromatic ring and the guanidine residue is 6.0 (2)°.
متن کاملAmiloride: the "new" renal tonic?
SODIUM REABSORPTION in the aldosterone-sensitive distal nephron is mediated by the amiloride-sensitive, epithelial sodium channels (ENaC), which are expressed in the apical (luminal) membranes. The regulated reabsorption of sodium at these nephron sites plays a key role in the regulation of extracellular fluid volume and systemic blood pressure (14, 15). The importance of ENaC in these processe...
متن کاملDiamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.
Diamine oxidase (histaminase), an enzyme that oxidatively deaminates putrescine and histamine, was purified from human placenta and from pig kidney. Both NH2-terminal sequences are highly homologous to the human kidney amiloride-binding protein, previously thought to be a component of the amiloride-sensitive Na+ channel. Monoclonal antibodies raised against the pig kidney amiloride-binding prot...
متن کاملAmiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: A clinical trial
Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was 4.3±0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two gr...
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ژورنال
عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System
سال: 2020
ISSN: 1470-3203,1752-8976
DOI: 10.1177/1470320320975893